Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ML-133 (hydrochloride), Purity: ≥98%, CAS: 1222781-70-5, 5 mg
A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal
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Medchemexpress LLC Azido-PEG1-C2-acid | 1393330-34-1 | 98.0% | 159.14 | 100 MG
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Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in the synthesis of PROTACs
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Cayman Chemical Dabcyl-K-SARS-CoV-2 Replicase Polyprotein 1ab (3235-3246)-E-EDANS (trifluoroacetate salt), Purity: ≥90%, 5 mg
A fluorogenic substrate for SARS-CoV and SARS-CoV-2 Mpro; upon enzymatic cleavage by SARS-CoV or SARS-CoV-2 Mpro at the Gln-Ser site, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify SARS-CoV or SARS-CoV-2 Mpro activity
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Cayman Chemical Nimbin, Purity: ≥98%, CAS: 5945-86-8, 5 mg
A limonoid with diverse biological activities; inhibits the growth of D. oryzae by 64.8% at 1,000 ppm; has antifeedant activity against S. littoralis in a choice test at 0.02-2,000 μM; decreases melanin content to 20.9% of control in B16 murine melanoma cells at 25 μg/ml; inhibits TPA-induced activation of EBV-EA in Raji cells (IC50 = 499 mol ratio/32 pmol TPA)
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Medchemexpress LLC HY-N0222 5mg Medchemexpress, Avicularin CAS:572-30-5 Purity:>98%
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Medchemexpress, HY-N0222 5mg Avicularin CAS:572-30-5 Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Cayman Chemical CC-122, Purity: ≥98%, CAS: 1015474-32-4, 50 mg
A pleiotropic pathway modifier with anticancer activity; binds to cereblon in U266 multiple myeloma cell extracts; induces recruitment and degradation of Aiolos and Ikaros in TMD8, OCI-LY10, and Karpas 422 DLBCL cells at 0.1, 1, and 10 μM; decreases proliferation and induces apoptosis ABC and GCB DLBCL cell lines from 0.1-10,000 nM; stimulates IL-2 production in mouse primary T cells; decreases tumor levels of Aiolos and Ikaros and reduces tumor growth in OCI-LY10 ABC DLBCL and WSU-DLCL2 GCB DLBCL mouse xenograft models
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Cayman Chemical NSC 668394, Purity: ≥98%, CAS: 382605-72-3, 25 mg
An ezrin binder (Kd = 10.6 µM); inhibits PKCι-induced phosphorylation of ezrin in a cell-free assay (IC50 = 8.1 µM); inhibits the interaction between ezrin and actin in K7M2 cells at 10 µM; reduces bacterial invasion but is not bactericidal in HEp-2 cells cells infected with GAS at 10 µM; induces developmental delays and cyclopia in Xenopus larvae at 10 µM and induces toxicity at 40 µM
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Medchemexpress LLC Lck Inhibitor 10mM | 847950-09-8 | 1 ML
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Lck inhibitor is a small-molecule kinase inhibitor (CAS 847950-09-8) that potently inhibits Lck and shows activity against Lyn, Src, and Syk. It is supplied for research use and is soluble in DMSO for stock preparation; storage recommendations include -20°C for powder and -80°C for solutions.
- Potent Lck inhibition (IC50 7 nM).
- Activity against Lyn, Src, and Syk.
- Molecular weight 530.62 g/mol; formula C31H30N8O.
- High DMSO solubility for stock preparation.
- Storage: powder at -20°C; solutions at -80°C.
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Cayman Chemical AZ 33, Purity: ≥98%, CAS: 1370290-34-8, 10 mg
An inhibitor of LDHA (Kd = 0.093 μM; IC50 = 0.5 μM); selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 μM, respectively); cell-impermeable and lacks cytotoxicity against HeLa cervical cancer cells (IC50 = >500 μM)
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Cayman Chemical HAMNO, Purity: ≥95%, CAS: 138736-73-9, 10 mg
A small molecule inhibitor of RPA; selectively binds to and inhibits DBD-F on RPA70 up to 100 µM; inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells at 10 and 20 µM; reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models at 1 mg/kg when used in combination with etoposide
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Medchemexpress LLC Human IgG1 L234A L2 25mg | 25mg
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Human IgG1 (L234AL235A) kappa Isotype Control a human monoclonal antibody is an isotype control for human IgG1 antibody
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Cayman Chemical KW 2449, Purity: ≥98%, CAS: 1000669-72-6, 25 mg
A multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo
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Cayman Chemical ANTIBODY SAR405 500ug
A selective inhibitor of Vps34 (IC50 = 1.2 nM); alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation; synergizes with everolimus in preventing the proliferation of renal tumor cell lines
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Medchemexpress LLC (Rac)-TBAJ-876 | 2131784-39-7 | 99.9% | 100 MG
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(Rac)-TBAJ-876 is a racemate of TBAJ-876. It is an inhibitor of *mycobacterium tuberculosis* and an analogue of the anti-tuberculosis agent Bedaquiline. It has potential for tuberculosis research.
- Racemate of TBAJ-876
- Inhibitor of mycobacterium tuberculosis
- Analogue of the anti-tuberculosis agent Bedaquiline
- Potential for tuberculosis research
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Selleck Chemical LLC MP-513 hydrobromide hydrate E4814-1G
Teneligliptin Hydrobromide Hydrate(MP-513 hydrobromide hydrate) is a potent competitive and long-lasting inhibitor of DPP-4 It competitively inhibited rhDPP-4 human plasma and rat plasma with IC50 values of 0 889 1 75 and 1 35 nM respectively It suppresses high glucose-mediated mitochondrial dysfunction and can be used for treatment of type 2 diabetes
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